|
KMID : 0356419990170020099
|
|
Journal of Korean Andrology
1999 Volume.17 No. 2 p.99 ~ p.106
|
|
|
Effects of Serotonergic Drugs on Intraluminal Pressure of Vas Deferent Induced by Electrical Stimulation of Rat Hypogastric Nerve
|
|
Seo Kyung-Keun
Kwak Seung-Min
Kim Sae-Chul
|
|
|
Abstract
|
|
|
Purpose: To compare the effects of various serotonergic drugs on the inhibition of
intraluminal pressure rise in the rat vas deferens induced by electrical stimulation of the
hypogastric nerve.
Material and Methods: Twenty-five Sprague Dawley rats (250∼300 gm) were
randomly divided into five groups of five animals each, which received intravenous
injection of normal saline, clomipramine, sertraline, paroxetine, or fluoxetine. Before
(baseline pressure) and 30 minutes after intravenous injection of four different doses (0.1
to 20 the therapeutic dose) of each agent, the hypogastric nerve, identified using
microsurgical technique, was electrically stimulated, and the intraluminal pressure of the
vats deferens was measured (central effect group). To evaluate the peripheral effects of
clomipramine and sertraline, intraluminal vassal pressure was also measured after
transaction of all proximal sympathetic nerves projecting to the hypogastric nerve and
the commissural branches between the right and left major and accessory pelvic ganglia.
The adrenal veins were ligated bilaterally.
Results: Repeated stimulation of the hypogastric nerves, anesthesia of long duration (3
hours), and repeated intravenous injection of normal saline did not result in significant
changes in the intraluminal pressure of the vats deferens. All serotonergic agents
inhibited elevation of the intraluminal pressure of the vas deferens in a dosedependent
manner (p<0.05). The extent of inhibition by 20-fold therapeutic doses of clomipramine,
sertraline, paroxetine and fluoxetine were 74.4±1.8%, 34.1±8.3%, 24.8±7.8%, and 8.1±
3.5%, respectively. At doses 10- and 20-fold the therapeutic dose, clomipramine had the
strongest inhibitory effect, followed by sertraline and paroxetine, then fluoxetine
(p<0.05). Definite inhibition was noted in all rats receiving clomipramine at 10- and
20-fold the therapeutic dose; the degree of inhibition was 80% in the sertraline-, 60% in
the paroxetine-, and 20% in the fluoxetine-treated group. The inhibitory effect of
sertraline on the elevation of the intraluminal vasal pressure in the peripheral-effect
group was significantly (p<0.01) less than that in the central-effect group. However,
there was no difference in the inhibitory effect of clomipramine in the two groups.
Conclusion: Clomipramine was the most potent inhibitor of the elevation of the
intraluminal pressure of the rat vats after electrical stimulation of the hypogastric nerve.
The greater effect might be attributable to an additional peripheral effect of this drug on
the was deferens.
|
|
|
KEYWORD
|
|
|
Vas deferens, Electrical stimulation, Hypogastric nerve, Rat, Serotonergic agent,
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|